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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CACNA1B All Species: 13.64
Human Site: S753 Identified Species: 30
UniProt: Q00975 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q00975 NP_000709.1 2339 262496 S753 P M S A A N I S I A A R Q Q N
Chimpanzee Pan troglodytes XP_520396 2784 310342 S1202 P M S A A N I S I A A R Q Q N
Rhesus Macaque Macaca mulatta XP_001110352 2383 269535 P744 P M S A P N M P S I E R D R R
Dog Lupus familis XP_537779 2046 229120 M577 Q G G V S K G M F S S F Y F I
Cat Felis silvestris
Mouse Mus musculus O55017 2327 261463 S753 P M S A A N I S I A A R Q Q N
Rat Rattus norvegicus Q02294 2336 262238 S754 P M S A A N I S I A A R Q Q N
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus O73700 2190 249326 I630 T I L V E L E I M S P L G I S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q2XVR3 1829 207718 G360 Y T S Y D N F G W A F L A L F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91645 1851 212452 R381 R R R N A A K R K K L K S L G
Honey Bee Apis mellifera NP_001159376 1904 215872 M435 I V L G S F F M L N L V L G V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001186699 1966 222605 L497 V L R A L R L L R I F K V T R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 82.1 54.2 80.1 N.A. 91.9 92.1 N.A. N.A. 38.3 N.A. 20.7 N.A. 44.7 47.6 N.A. 39.5
Protein Similarity: 100 82.3 65.5 82.2 N.A. 94.4 94.5 N.A. N.A. 53.3 N.A. 36 N.A. 56 58.7 N.A. 52.4
P-Site Identity: 100 100 40 0 N.A. 100 100 N.A. N.A. 0 N.A. 20 N.A. 6.6 0 N.A. 6.6
P-Site Similarity: 100 100 53.3 20 N.A. 100 100 N.A. N.A. 26.6 N.A. 20 N.A. 13.3 20 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 55 46 10 0 0 0 46 37 0 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 10 0 0 0 0 0 0 0 10 0 0 % D
% Glu: 0 0 0 0 10 0 10 0 0 0 10 0 0 0 0 % E
% Phe: 0 0 0 0 0 10 19 0 10 0 19 10 0 10 10 % F
% Gly: 0 10 10 10 0 0 10 10 0 0 0 0 10 10 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 10 0 0 0 0 37 10 37 19 0 0 0 10 10 % I
% Lys: 0 0 0 0 0 10 10 0 10 10 0 19 0 0 0 % K
% Leu: 0 10 19 0 10 10 10 10 10 0 19 19 10 19 0 % L
% Met: 0 46 0 0 0 0 10 19 10 0 0 0 0 0 0 % M
% Asn: 0 0 0 10 0 55 0 0 0 10 0 0 0 0 37 % N
% Pro: 46 0 0 0 10 0 0 10 0 0 10 0 0 0 0 % P
% Gln: 10 0 0 0 0 0 0 0 0 0 0 0 37 37 0 % Q
% Arg: 10 10 19 0 0 10 0 10 10 0 0 46 0 10 19 % R
% Ser: 0 0 55 0 19 0 0 37 10 19 10 0 10 0 10 % S
% Thr: 10 10 0 0 0 0 0 0 0 0 0 0 0 10 0 % T
% Val: 10 10 0 19 0 0 0 0 0 0 0 10 10 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % W
% Tyr: 10 0 0 10 0 0 0 0 0 0 0 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _